Resarch
Recent data imply that the human genome is pervasively transcribed and encodes tens of thousands of noncoding RNA (ncRNA) transcripts that play important regulatory roles in a wide array of cellular processes. Our main focus is to understand the biological functions of different classes of ncRNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in human health and disease. We are currently pursuing several research projects that explore the roles of ncRNAs and RNA editing in the pathogenesis of cancer, cardiovascular disease, non-alcoholic steatohepatitis (NASH), and obesity. Our long-term goal is to translate discoveries in RNA biology into novel RNA-based therapeutic strategies for the treatment of life-threatening diseases.
Resarch
Recent data imply that the human genome is pervasively transcribed and encodes tens of thousands of noncoding RNA (ncRNA) transcripts that play important regulatory roles in a wide array of cellular processes. Our main focus is to understand the biological functions of different classes of ncRNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in human health and disease. We are currently pursuing several research projects that explore the roles of ncRNAs and RNA editing in the pathogenesis of cancer, cardiovascular disease, non-alcoholic steatohepatitis (NASH), and obesity. Our long-term goal is to translate discoveries in RNA biology into novel RNA-based therapeutic strategies for the treatment of life-threatening diseases.