Although lncRNAs have been of great interested in the research community, their functions in cardiovascular disease are largely unknown. Using bioinformatics to generate novel hypotheses followed by in vitro and in vivo experiments in human cells and animal models, we have identified novel lncRNAs (e.g., Airn, LINC00324, LOC400043, Myolinc) and are currently elucidating their functions in the heart. Among the lncRNAs, one in particular is interesting, as we were the first team to identify an additional function of the well-known paternally imprinted lncRNA gene, Airn. Using cardiomyocytes and mouse models, we demonstrated that: (i) Airn is highly expressed in the heart; (ii) it is preferentially localized in the nucleus; (iii) silencing of Airn augments vulnerability to cell death and reduces cell migration; (iv) its expression is down-regulated following myocardial infarction; and (v) Airn binds to the RNA-binding protein Igf2bp2 and controls translation of Igf2bp2 and other genes (e.g. biglycan, Inhba) (Circulation Research, 2018).